Tendon & Ligament Models
Multiple studies in rodent models have examined BPC-157's effects on tendon-to-bone healing, including Achilles tendon transection models. Researchers observed changes in fibroblast activity and collagen organization.
Overview
What is BPC-157?
BPC-157 is a synthetic pentadecapeptide consisting of 15 amino acids, derived from a sequence found in human gastric juice. One of the most extensively studied peptides in modern research, with over 100 peer-reviewed publications examining its biological mechanisms across gastrointestinal, musculoskeletal, vascular, and neurological systems.
BPC-157 (Body Protection Compound) is supplied strictly as a reference material for in vitro and preclinical investigation. All characterization data described here is drawn from peer-reviewed literature and laboratory analysis; nothing herein constitutes a claim of clinical effect in humans.
Investigational Scope
Documented Research Areas
The following domains summarize directions explored across published studies and laboratory models. Each reflects observations reported in rodent models, in vitro systems, or the peer-reviewed record.
GI Tract Biology
Given its origin from gastric juice, GI research has been a primary focus. Studies have examined mucosal integrity, ulcer models, and inflammatory bowel disease models in rodents.
Angiogenesis Research
Research has documented BPC-157's interaction with VEGF signaling pathways. Studies suggest upregulation of VEGFR2 expression in endothelial cell cultures.
CNS & Dopaminergic Systems
A subset of research has examined BPC-157 in the context of dopamine system modulation, including studies on dopamine receptor activity in rat models.
Proposed Mechanism
Mechanistic Pathway
Mechanistic steps below are hypothesized from in vitro assays and animal-model data reported in the literature. They describe biochemical interactions observed under controlled experimental conditions.
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1
VEGF Pathway Interaction
Research indicates BPC-157 may upregulate VEGFR2 (KDR/Flk-1) expression, central to angiogenesis and observed wound healing activity in animal models.
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2
Nitric Oxide System Modulation
Studies have documented interactions between BPC-157 and the nitric oxide system, with both NO-dependent and NO-independent effects proposed across various rodent models.
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3
Growth Hormone Receptor Sensitization
Some researchers have proposed that BPC-157 may interact with growth hormone receptor signaling, potentially enhancing receptor sensitivity rather than directly stimulating GH production.
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4
Fibroblast & Collagen Activity
In vitro studies have demonstrated BPC-157's ability to stimulate fibroblast migration and proliferation, with downstream effects on collagen synthesis in connective tissue models.
Technical Data
Molecular Specifications
| Amino Acid Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
|---|---|
| Molecular Weight | 1,419.5 g/mol |
| Molecular Formula | C₆₂H₁₀₀N₁₆O₂₂ |
| CAS Number | 137525-51-0 |
| Storage | −20°C long-term, 4°C short-term up to 4 weeks |
References
Selected Literature
The following peer-reviewed references informed the research summaries on this page. Citations are provided for scientific context only.
- Sikiric P, et al. (2018). Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Current Pharmaceutical Design, 24(18), 1938–1956.
- Chang CH, et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 110(3), 774–780.
- Hsieh MJ, et al. (2017). Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine, 95(3), 323–333.
- Sikiric P, et al. (2016). Brain-gut Axis and Pentadecapeptide BPC 157. Current Neuropharmacology, 14(8), 857–865.
- Tudor M, et al. (2010). Gastric pentadecapeptide BPC 157 counteracts peripheral nociceptive signaling and interacts with NO system. Inflammopharmacology, 18(6), 291–300.
Research Disclaimer
This product is intended strictly for laboratory research purposes only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or animal consumption. All information presented is derived from published scientific literature and is provided for educational reference only. By purchasing, the buyer affirms they are a qualified researcher or institution and assume full responsibility for the safe and lawful handling of this material.