Small Fiber Models
ARA-290 has been investigated in peripheral nerve and small-fiber research models involving repair signaling and inflammatory stress.
Overview
What is ARA-290?
ARA-290, also known as cibinetide, is an 11-amino-acid peptide derived from the tissue-protective region of erythropoietin. It is studied for signaling through innate repair receptor pathways, with laboratory research focused on inflammatory, neuroprotective, and small-fiber biology models.
ARA-290 (Cibinetide) is supplied strictly as a reference material for in vitro and preclinical investigation. All characterization data described here is drawn from peer-reviewed literature and laboratory analysis; nothing herein constitutes a claim of clinical effect in humans.
Investigational Scope
Documented Research Areas
The following domains summarize directions explored across published studies and laboratory models. Each reflects observations reported in rodent models, in vitro systems, or the peer-reviewed record.
Innate Repair Signaling
Researchers study ARA-290 for activation of tissue-protective receptor pathways without erythropoietic activity.
Inflammatory Metabolic Models
Published studies have examined ARA-290 in metabolic and inflammatory models where tissue stress and immune signaling intersect.
Cytoprotection Research
The peptide is used to examine cellular survival pathways, cytokine modulation, and tissue response under controlled injury models.
Proposed Mechanism
Mechanistic Pathway
Mechanistic steps below are hypothesized from in vitro assays and animal-model data reported in the literature. They describe biochemical interactions observed under controlled experimental conditions.
-
1
Innate Repair Receptor Binding
ARA-290 is studied for interaction with the erythropoietin receptor beta common receptor heterocomplex associated with tissue-protective signaling.
-
2
Non-Erythropoietic Activity
Unlike full erythropoietin, ARA-290 is designed for tissue-protective pathway research without stimulating red blood cell production pathways.
-
3
Cytokine Modulation
Laboratory models have examined changes in inflammatory cytokine signaling and immune-cell activation following ARA-290 exposure.
-
4
Neuronal Support Pathways
Research explores downstream effects on neurite integrity, small-fiber density markers, and stress-response signaling in nerve-related models.
Technical Data
Molecular Specifications
| Amino Acid Sequence | Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
|---|---|
| Molecular Weight | 1,257.4 g/mol |
| Molecular Formula | C51H84N16O21 |
| CAS Number | 1208243-50-8 |
| Storage | -20°C long-term, 4°C short-term up to 4 weeks |
References
Selected Literature
The following peer-reviewed references informed the research summaries on this page. Citations are provided for scientific context only.
- Brines M, et al. (2008). ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathy. Molecular Medicine, 14(5-6), 292-305.
- Brines M & Cerami A. (2012). The receptor that tames the innate immune response. Molecular Medicine, 18, 486-496.
- Heij L, et al. (2012). Cibinetide in inflammatory and neuropathic research models. Molecular Medicine, 18, 1090-1099.
- Leist M, et al. (2004). Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science, 305(5681), 239-242.
- Cerami A. (2012). Beyond erythropoiesis: novel applications for recombinant human erythropoietin. Seminars in Hematology, 49(2), 100-106.
Research Disclaimer
This product is intended strictly for laboratory research purposes only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or animal consumption. All information presented is derived from published scientific literature and is provided for educational reference only. By purchasing, the buyer affirms they are a qualified researcher or institution and assume full responsibility for the safe and lawful handling of this material.