GH Axis Stimulation
CJC-1295 No DAC has been studied for its ability to stimulate pulsatile GH release via GHRH receptor activation in rodent and primate models, preserving the natural GH secretion pattern.
Overview
What is CJC-1295 No DAC?
CJC-1295 No DAC is a synthetic analogue of growth hormone-releasing hormone (GHRH), modified to enhance stability while retaining a shorter half-life compared to the DAC version. Research has focused on its ability to stimulate pulsatile growth hormone secretion in animal models, making it a subject of interest in GH axis biology and metabolic research.
CJC-1295 No DAC (CJC-1295 Without Drug Affinity Complex) is supplied strictly as a reference material for in vitro and preclinical investigation. All characterization data described here is drawn from peer-reviewed literature and laboratory analysis; nothing herein constitutes a claim of clinical effect in humans.
Investigational Scope
Documented Research Areas
The following domains summarize directions explored across published studies and laboratory models. Each reflects observations reported in rodent models, in vitro systems, or the peer-reviewed record.
IGF-1 & Metabolic Markers
Studies have documented downstream increases in IGF-1 following CJC-1295 administration in animal models, with associated observations in lean mass and fat metabolism markers.
Half-Life & Stability Research
The No DAC formulation provides a shorter half-life than the DAC version, enabling research into pulsatile vs. sustained GH release patterns and receptor desensitization dynamics.
GHRP Synergy Studies
CJC-1295 No DAC is frequently studied in combination with GHRPs such as Ipamorelin in animal models, with researchers examining synergistic effects on GH pulse amplitude.
Proposed Mechanism
Mechanistic Pathway
Mechanistic steps below are hypothesized from in vitro assays and animal-model data reported in the literature. They describe biochemical interactions observed under controlled experimental conditions.
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1
GHRH Receptor Agonism
CJC-1295 binds and activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, stimulating the synthesis and pulsatile release of growth hormone.
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2
cAMP Signaling Cascade
GHRHR activation triggers adenylyl cyclase, increasing intracellular cAMP and activating protein kinase A, which drives GH gene transcription and secretory vesicle release.
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3
IGF-1 Upregulation
GH released in response to CJC-1295 stimulates hepatic IGF-1 production, a downstream mediator studied for its role in protein synthesis and metabolic regulation in animal models.
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4
Pulsatility Preservation
Unlike long-acting GHRH analogues, the No DAC formulation's shorter half-life preserves pulsatile GH release patterns, which researchers consider important for avoiding receptor downregulation.
Technical Data
Molecular Specifications
| Amino Acid Sequence | Tyr-DAla-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ |
|---|---|
| Molecular Weight | 3,367.9 g/mol |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| CAS Number | 863288-34-0 |
| Storage | −20°C long-term, 4°C short-term up to 4 weeks |
References
Selected Literature
The following peer-reviewed references informed the research summaries on this page. Citations are provided for scientific context only.
- Teichman SL, et al. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone. Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805.
- Alba M, et al. (2006). Once-monthly administration of CJC-1295, a long-acting growth hormone-releasing hormone analog, normalizes growth in GH-deficient rats. American Journal of Physiology, 291(6), E1290–E1294.
- Ionescu M & Frohman LA. (2006). Pulsatile secretion of growth hormone mediated by growth hormone-releasing hormone in rats. Endocrinology, 147(1), 299–306.
- Popovic V, et al. (1995). Growth hormone-releasing hormone self-priming. Acta Endocrinologica, 132(2), 168–173.
- Mayo KE, et al. (1995). Growth hormone-releasing hormone: synthesis and signaling. Recent Progress in Hormone Research, 50, 35–73.
Research Disclaimer
This product is intended strictly for laboratory research purposes only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or animal consumption. All information presented is derived from published scientific literature and is provided for educational reference only. By purchasing, the buyer affirms they are a qualified researcher or institution and assume full responsibility for the safe and lawful handling of this material.