Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by researchers at the St. Petersburg Institute of Bioregulation and Gerontology. Research has examined its effects on pineal gland biology, circadian regulation, neuroprotection, and age-related cognitive decline in cell culture and animal models.
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by researchers at the St. Petersburg Institute of Bioregulation and Gerontology. Research has examined its effects on pineal gland biology, circadian regulation, neuroprotection, and age-related cognitive decline in cell culture and animal models.
Pinealon (Pinealon Tripeptide (Glu-Asp-Arg)) is supplied strictly as a reference material for in vitro and preclinical investigation. All characterization data described here is drawn from peer-reviewed literature and laboratory analysis; nothing herein constitutes a claim of clinical effect in humans.
The following domains summarize directions explored across published studies and laboratory models. Each reflects observations reported in rodent models, in vitro systems, or the peer-reviewed record.
Pinealon has been studied for its effects on pineal gland function and melatonin biosynthesis regulation in rodent models. Research has examined its role in circadian rhythm modulation and sleep-wake cycle regulation.
Studies have examined Pinealon's neuroprotective effects in models of oxidative stress, hypoxia, and age-related neurodegeneration, with documented effects on neuronal survival markers.
Russian research groups have examined Pinealon in aged rodent models, observing improvements in spatial memory and learning parameters alongside reductions in oxidative stress markers in brain tissue.
Research has examined Pinealon's ability to penetrate cell nuclei and interact with chromatin, suggesting potential epigenetic mechanisms underlying its observed biological activity in cell culture.
Mechanistic steps below are hypothesized from in vitro assays and animal-model data reported in the literature. They describe biochemical interactions observed under controlled experimental conditions.
Research suggests Pinealon modulates pinealocyte activity and melatonin biosynthesis pathway components, with studies documenting changes in serotonin-N-acetyltransferase (SNAT) activity in pineal tissue.
Studies have documented Pinealon-mediated increases in superoxide dismutase and catalase activity in brain tissue of aged rodents, correlating with reduced lipid peroxidation markers.
In vitro research has examined Pinealon's effects on neuronal survival under oxidative and hypoxic stress conditions, with observed upregulation of BDNF and anti-apoptotic protein expression.
Research has proposed that Pinealon, as a short peptide bioregulator, may interact directly with DNA regulatory sequences, modulating gene expression patterns relevant to neuronal function and aging.
| Amino Acid Sequence | Glu-Asp-Arg |
|---|---|
| Molecular Weight | 417.4 g/mol |
| Molecular Formula | C₁₅H₂₅N₅O₈ |
| CAS Number | N/A |
| Storage | −20°C long-term, 4°C short-term up to 4 weeks |
The following peer-reviewed references informed the research summaries on this page. Citations are provided for scientific context only.
This product is intended strictly for laboratory research purposes only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or animal consumption. All information presented is derived from published scientific literature and is provided for educational reference only. By purchasing, the buyer affirms they are a qualified researcher or institution and assume full responsibility for the safe and lawful handling of this material.